Primary Neurons

//Primary Neurons
Primary Neurons 2018-10-02T05:09:08+00:00

Cell Cultures / Primary Neurons

Spinal Cord
Olfactory Placode


Does Representation of Outer Objects in Living Neuronal Network Synthesize “the concept”?
E Shibata, H atsu Ito, W Minoshima, SN KudohkCA
IEEE. doi: 10.1109/SCIS-ISIS.2016.0125

Effects of copper on viability and functional properties of hippocampal neurons in vitro.

Kapkaeva MR, Popova OV, Kondratenko RV, Rogozin PD, Genrikhs EE, Stelmashook EV, Skrebitsky VG, Khaspekov LG, Isaev NK.
Exp Toxicol Pathol. 2017 Feb 8. pii: S0940-2993(16)30140-3. doi: 10.1016/j.etp.2017.01.011

TrkB-Mediated neuroprotective and antihypoxic propaerties of brain-derived neurotrophic.
Vedunova MV, Mishchenko TA, Mitroshina EV, Mukhina IV.
Oxid Med Cell Longev. 2015;2015:453901.

Synchronized code sequences from spike trains in cultured neuronal networks.
Nishitani Y, Hosokawa C, Mizuno-Matsumoto Y, Miyoshi T, Sawai H, Tamura S.
IJEI, 2014 Sep, 5, 12-24.

PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms.
Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ.
Toxicol Sci. 2014 Apr;138(2):379-92.

Dynamic transitions among multipule oscillators of synchronized bursts in cultured neural networks.
Kim JH, Heo R, Choi JH, Lee KJ.
J. Stat. Mech., 2014 Apr, P04019.

Carbon nanotube multi-electrode array chips for noninvasive real-time measurement of dopamine, action potentials, and postsynaptic potentials.
Suzuki I, Fukuda M, Shirakawa K, Jiko H, Gotoh M.
Biosens Bioelectron. 2013 Nov 15;49:270-5.

A three-dimensional neuronal culture technique that controls the direction of neurite elongation and the position of soma to mimic the layered structure of the brain.
Odawara A, Gotoh M, Suzuki I.
RSC Adv. 2013 3, 23620-23630 .

Temporal dynamics of a homeostatic pathway controlling neural network activity.
Bateup HS , Denefrio CL, Johnson CA, Saulnier JL, Sabatini BL.
Front Mol Neurosci. 2013 Sep 18;6:28.

Seizure-like activity in hyaluronidase-treated dissociated hippocampal cultures.
Vedunova M, Sakharnova T, Mitroshina E, Perminova M, Pimashkin A, Zakharov Y,Dityatev A, Mukhina I.
Front Cell Neurosci. 2013 Sep 12;7:149.

Adaptive enhancement of learning protocol in hippocampal cultured networks grown on multielectrode arrays.
Pimashkin A, Gladkov A, Mukhina I, Kazantsev V.
Front Neural Circuits. 2013 May 24;7:87.

Excitatory/Inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis.
Bateup HS, Johnson CA, Denefrio CL, Saulnier JL, Kornacker K, Sabatini BL.
Neuron. 2013 May 8;78(3):510-22.

Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity.
Alhibshi AH, Gotoh M, Suzuki I.
Biochem Biophys Res Commun. 2013 Apr 19;433(4):362-7.

A study of epileptogenic network structures in rat hippocampal cultures using first spike latencies during synchronization events.
Raghavan M, Amrutur B, Srinivas KV, Sikdar SK.
Phys Biol. 2012 Oct;9(5):056002.

Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.
Cao Z, Hulsizer S, Tassone F, Tang HT, Hagerman RJ, Rogawski MA, Hagerman PJ, Pessah IN.
Hum Mol Genet. 2012 Jul 1;21(13):2923-35.

Detection of M-sequences from spike sequence in neuronal networks.
Nishitani Y, Hosokawa C, Mizuno-Matsumoto Y, Miyoshi T, Sawai H, Tamura S.
Comput Intell Neurosci. 2012;2012:862579.

Spiking signatures of spontaneous activity bursts in hippocampal cultures.
Pimashkin A, Kastalskiy I, Simonov A, Koryagina E, Mukhina I, Kazantsev V.
Front Comput Neurosci. 2011 Nov 11;5:46.

Rapid modulation of local neural activity by controlled drug release from polymer-coated recording microelectrodes.
Stauffer WR, Lau PM, Bi GQ, Cui XT.
J Neural Eng. 2011 Aug;8(4):044001.

Effects of electrical stimulation on autonomous electrical activity in a cultured rat hippocampal neuronal network.
Kiyohara A, Taguchi T, Kudoh SN.
IEEJ Trans Elec Electron Eng. 2011 Jan 18;6(2):163-7.

Paradigms representing the relationship between the inner of a brain and the outer world.
Kudoh SN, Kiyohara A, Tokuda M, Taguchi T.
IEEJ Trans Elec Electro Eng. 2010 Nov 10;6(1):51-7.

Micro-channel fabrication by femtosecond laser to arrange neuronal cells on multi-electrode arrays.
Hosokawa C, Kudoh SN, Suzuki M, Kiyohara A, Hosokawa Y, Okano K, Masuhara H, Taguchi T.
Applied Physics A. 2010 Nov; 101(2), 423-8.

The heterogeneous distribution of functional synaptic connections in rat hippocampal dissociated neuron cultures.
Kudoh S. N. et. al.
Electron Commun Jpn. 2009 June;92(6), 41-9.

Resynchronization in neuronal network divided by femtosecond laser processing.
Hosokawa C, Kudoh SN, Kiyohara A, Taguchi T.
Neuroreport. 2008 May 7;19(7):771-5.

Detection of tetanus-induced effects in linearly lined-up micropatterned neuronal networks: application of a multi-electrode array chip combined with agarose microstructures.
Suzuki I, Yasuda K.
Biochem Biophys Res Commun. 2007 May 4;356(2):470-5.

Small-world network topology of hippocampal neuronal network is lost, in and in vitro glutamate injury model of epilepsy.
Srinivas KV, Jain R, Saurav S, Sikdar SK.
Eur J Neurosci. 2007 Jun;25(11):3276-86.

Biomodeling system-interaction between living neuronal networks and the outer world.
Kudoh SN, Hosokawa C, Kiyohara A, Taguchi T, Hayashi I.
J Robot Mechatron. 2007 May;19(5):559-600.

Stepwise pattern modification of neuronal network in photo-thermally-etched agarose architecture on multi-electrode array chip for individual-cell-based electrophysiological measurement.
Suzuki I, Sugio Y, Jimbo Y, Yasuda K.
Lab Chip. 2005 Mar;5(3):241-7.

Operation of spatiotemporal patterns stored in living neuronal networks cultured on a microelectrode array.
Kudoh SN, Taguchi T.
J Adv Comp Intel Intel Info. 2004;8(2):100-7.

A simple exploratory algorithm for the accurate and fast detection of spontaneous synaptic events.
Kudoh SN, Taguchi T.
Biosens Bioelectron. 2002 Sep;17(9):773-82.

Techniques for patterning and guidance of primary culture neurons on micro-electrode arrays.
Griscom L, Degenaarb P, LePiouflec B, Tamiya E, Fujita H.
Sens. Actuators B. Chem. 2002 Mar, 83, 15-21.


Measurement of saturation processes in glutamatergic and GABAergic synapse densities during long-term development of cultured rat cortical networks.
Ito D, Komatsu T, Gohara K.
Brain Res. 2013 Oct 9;1534:22-32

Neuronal cell patterning on a multi-electrode array for a network analysis platform.
Suzuki M, Ikeda K, Yamaguchi M, Kudoh SN, Yokoyama K, Satoh R, Ito D, Nagayama M, Uchida T, Gohara K.
Biomaterials. 2013 Jul;34(21):5210-7.

Xenon-induced inhibition of synchronized bursts in a rat cortical neuronal network.
Uchida T, Suzuki S, Hirano Y, Ito D, Nagayama M, Gohara K.
Neuroscience. 2012 Jul 12;214:149-58.

Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II.
Saha RN, Wissink EM, Bailey ER, Zhao M, Fargo DC, Hwang JY, Daigle KR, Fenn JD, Adelman K, Dudek SM.
Nat Neurosci. 2011 May 29;14(7):848-56.

Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity.
Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN.
Environ Health Perspect. 2011 Apr;119(4):519-26.

Minimum neuron density for synchronized bursts in a rat cortical culture on multi-electrode arrays.
Ito D, Tamate H, Nagayama M, Uchida T, Kudoh SN, Gohara K.
Neuroscience. 2010 Nov 24;171(1):50-61.

Estimation of functional connectivity that causes burst-like population activities.
Nomura M, Ito D, Tamate H, Gohara K, Aoyagi T.
Forma. 2009;24,11-6.

Elevated synaptic activity preconditions neurons against an in vitro model of ischemia.
Tauskela JS, Fang H, Hewitt M, Brunette E, Ahuja T, Thivierge JP, Comas T, Mealing GA.
J Biol Chem. 2008 Dec 12;283(50):34667-76.

Investigating neuronal activity with planar microelectrode arrays: achievements and new perspectives.
Morin FO, Takamura Y, Tamiya E.
J Biosci Bioeng. 2005 Aug;100(2):131-43.


Protein processing and releases of neuregulin-1 are regulated in an activity-dependent manner.
Ozaki M, Itoh K, Miyakawa Y, Kishida H, Hashikawa T.
J Neurochem. 2004 Oct;91(1):176-88.


Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus.
Ono D, Honma S, Honma K.
Nat Commun. 2013;4:1666.

Fast synchronous oscillations of firing rate in cultured rat suprachiasmatic nucleus neurons: possible role in circadian synchronization in the intact nucleus.
Kononenko NI, Honma S, Honma KI.
Neurosci Res. 2013 Mar;75(3):218-27.

On the role of calcium and potassium currents in circadian modulation of firing rate in rat suprachiasmatic nucleus neurons: multielectrode dish analysis.
Kononenko NI, Honma S, Dudek FE, Honma K.
Neurosci Res. 2008 Sep;62(1):51-7.

Diversity in the circadian periods of single neurons of the rat suprachiasmatic nucleus depends on nuclear structure and intrinsic period.
Honma S, Nakamura W, Shirakawa T, Honma K.
Neurosci Lett. 2004 Apr 1;358(3):173-6.

Circadian dynamics of cytosolic and nuclear Ca 2+ in single suprachiasmatic nucleus neurons.
Ikeda M, Sugiyama T, Wallace CS, Gompf HS, Yoshioka T, Miyawaki A, Allen CN.
Neuron. 2003 Apr 24;38(2):253-63.

Regional pacemakers composed of multiple oscillator neurons in the rat suprachiasmatic nucleus.
Nakamura W, Honma S, Shirakawa T, Honma K.
Eur J Neurosci. 2001 Aug;14(4):666-74.

Synchronization of circadian firing rhythms in cultured rat suprachiasmatic neurons.
Shirakawa T, Honma S, Katsuno Y, Oguchi H, Honma KI.
Eur J Neurosci. 2000 Aug;12(8):2833-8.

Synaptic communication of cellular oscillations in the rat suprachiasmatic neurons.
Honma S, Shirakawa T, Nakamura W, Honma K.
Neurosci Lett. 2000 Nov 17;294(2):113-6.

Circadian periods of single suprachiasmatic neurons in rats.
Honma S, Shirakawa T, Katsuno Y, Namihira M, Honma K.
Neurosci Lett. 1998 Jul 10;250(3):157-60.


Bacteria activate sensory neurons that modulate pain and inflammation.
Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ.
Nature. 2013 Sep 5;501(7465):52-7.

Spinal Cord

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.
Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH Jr, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ.
Cell Rep. 2014 Apr 10;7(1):1-1

Neuronal and network activity in networks of cultured spinal motor neurons.
Zhang HM, Robinson N, Gómez-Curet I, Wang W, Harrington MA.
Neuroreport. 2009 Jun 17;20(9):849-54.

Olfactory Placode

Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells.
Fujimoto Y, Abematsu M, Falk A, Tsujimura K, Sanosaka T, Juliandi B, Semi K, Namihira M, Komiya S, Smith A, Nakashima K.
Stem Cells. 2012 Jun;30(6):1163-73.

Effects of GABA and bicuculline on the electrical activity of rat olfactory placode neurons derived at E13.5 and cultured for 1 week on multi-electrode dishes.
Suyama K, Daikoku S, Funabashi T, Kimura F.
Endocr J. 2004 Apr;51(2):171-6.


Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).
Kimura I, Inoue D, Maeda T, Hara T, Ichimura A, Miyauchi S, Kobayashi M, Hirasawa A, Tsujimoto G.
Proc Natl Acad Sci U S A. 2011 May 10;108(19):8030-5.

Microtubule-associated protein 2-positive cells derived from microglia possess properties of functional neurons.
Matsuda S, Niidome T, Nonaka H, Goto Y, Fujimura K, Kato M, Nakanishi M, Akaike A, Kihara T, Sugimoto H. Biochem Biophys Res Commun. 2008 Apr 18;368(4):971-6.

A biosensing system based on extracellular potential recording of ligand-gated ion channel function overexpressed in insect cells.
Haruyama T, Bongsebandhu-Phubhakdi S, Nakamura I, Mottershead D, Keinanen K, Kobatake E, Aizawa M.
Anal Chem. 2003 Feb 15;75(4):918-21.

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