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• MED64 - An Advanced MEA Solution for In Vitro Electrophysiology
  • MED64: Products
    • MED64 System: A Complete System MEA Based System for In Vitro Electrophysiology.
    • MED8 System: The MED8 System Discontinued.
    • MED64 System: 64ch Integrated Amplifier
    • MED64 System: MED probe- 64 Planar Microelectrodes
    • MED64 System: MED64 Connector (MED-C03P) 
    • MED64 System: Software-Mobius
      • MED64 System: Mobius Trial Software 
  • MED64 Applications
    • MED64 Applications: Synaptic Activity- LTP & CSD
    • MED64 Applications: Biological Rhythms
    • MED64 Applications: Pharmacology- Drug Testing
    • MED64 Applications: Unit and Network Activity
    • MED64 Applications: Muscle Propagation and Pacing
    • MED64 Applications: Preparation Based Applications
    • MED64 Applications: QT Prolongation
    • MED64 - An Advanced MEA Solution for In Vitro Electrophysiology
  • MED64: Support Overview
  • MED64: Offices and Distributors
    • MED64: Request a Quote
    • MED64: About Alpha Med Sciences (JP)
    • MED64: General Contact Form
    • MED64: Testimonials
  • MED64: Resources for the MED64 System
    • MED64 Resources: Frequently Asked Questions
    • MED64 Reources: Technology- Patents, History and Testimonials
    • MED64 Resources: Utilities and Experimental Methods
    • MED64 Resources: Troubleshooting Guide
    • MED64 Resources: Testimonials from Pioneers in MEA
    • MED64 Resources: Movie Downloads- Current Source Density of Beta Rhythms
    • MED64 Resources: Community Forum
    • MED64 Resources: Symposiums- 2002 - 2006
    • MED64 Resources: Software- Demos, Upgrades and Manuals
    • MED64 Resources: Publications- Journals and Abstracts Articles
      • Zonisamide at clinically relevant concentrations inhibits field EPSP but not presynaptic fiber volley in rat frontal cortex.
      • Protective role of hydrogen peroxide in oxygen-deprived dopaminergic neurones of the rat substantia nigra.
      • Nonphotic entrainment of the circadian body temperature rhythm by the selective ORL1 receptor agonist W-212393 in rats.
      • Investigating neuronal activity with planar microelectrode arrays: achievements and new perspectives.
      • Synchronized retinal oscillations encode essential information for escape behavior in frogs.
      • Dephosphorylation and internalization of cell adhesion molecule L1 induced by theta burst stimulation in rat hippocampus.
      • Serotonergic modulation of carbachol-induced rhythmic activity in hippocampal slices.
      • Temporal properties of retinal ganglion cell responses to local transretinal current stimuli in the frog retina.
      • Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro.
      • Activity dependence of cortical axon branch formation: a morphological and electrophysiological study using organotypic slice cultures.
      • Hippocampal gamma-frequency oscillations: from interneurones to pyramidal cells, and back.
      • Conduction abnormality in gap junction protein connexin45-deficient embryonic stem cell-derived cardiac myocytes.
      • Spike Timing of Distinct Types of GABAergic Interneuron during Hippocampal Gamma Oscillations In Vitro.
      • Protein processing and releases of neuregulin-1 are regulated in an activity-dependent manner.
      • Protein kinase associated with gating and closing transmission mechanisms in temporoammonic pathway.
      • Rapid electrical stimulation of contraction modulates gap junction protein in neonatal rat cultured cardiomyocytes.
      • Electrophysiological characteristic of corticoaccumbens synapses in rat mesolimbic system reconstructed using organotypic slice cultures.
      • Effects of GABA and bicuculline on the electrical activity of rat olfactory placode neurons derived at E13.5 and cultured for 1 week on multi-electrode dishes.
      • Operation of spatiotemporal patterns stored in living neuronal networks cultured on a microelectrode array.
      • Diversity in the circadian periods of single neurons of the rat suprachiasmatic nucleus depends on nuclear structure and intrinsic period.
      • Novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation.
      • Synaptic plasticity preserved with arachidonic acid diet in aged rats.
      • MED64 Publications
      • Activity-Evoked Capacitative Ca2+ Entry: Implications in Synaptic Plasticity.
      • Circadian dynamics of cytosolic and nuclear ca 2+ in single suprachiasmatic nucleus neurons.
      • A biosensing system based on extracellular potential recording of ligand-gated ion channel function overexpressed in insect cells.
      • Age-dependent modulation of hippocampal excitability by KCNQ-channels.
      • Mossy fibre synaptic NMDA receptors trigger non-Hebbian long-term potentiation at entorhino-CA3 synapses in the rat.
      • Impaired M-current and neuronal excitability.
      • Chronic multichannel recordings from organotypic hippocampal slice cultures: protection from excitotoxic effects of NMDA by noncompetitive NMDA antagonists
      • Chronic exposure to trichloroethylene affects neuronal plasticity in rat hippocampal slices.
      • Asymmetrical distribution of the Schaffer projections within the apical dendrites of hippocampal field CA1.
      • A simple exploratory algorithm for the accurate and fast detection of spontaneous synaptic events.
      • Clock mutation lengthens the circadian period without damping rhythms in individual SCN neurons.
      • Regional pacemakers composed of multiple oscillator neurons in the rat suprachiasmatic nucleus.
      • Polysynaptic excitatory pathways induce heterosynaptic depression in the rat auditory cortex.
      • Immortalized Gonadotropin-Releasing Hormone Neurons (GT1-7 Cells) Exhibit Synchronous Bursts of Action Potentials.
      • Selective suppression of horizontal propagation in rat visual cortex by norepinephrine.
      • Origins and distribution of cholinergically induced beta rhythms in hippocampal slices.
      • Synchronization of circadian firing rhythms in cultured rat suprachiasmatic neurons.
      • Dysfunction of M-channel enhances propagation of neuronal excitability in rat hippocampus monitored by multielectrode dish and microdialysis systems.
      • Synaptic communication of cellular oscillations in the rat suprachiasmatic neurons.
      • A new planar multielectrode array for extracellular recording: application to hippocampal acute slice.
      • Circadian periods of single suprachiasmatic neurons in rats.
      • Long-term analysis of ltp in the hippocampal acute slice of mouse using multielectrode array recording.
      • Oscillatory neural activity in olfactory areas of molluscan brains recorded by a 64 electrode planar microarray.
      • Deficits in ca1 hippocampal long-term potentiation in tg2576 mice and its potential reversal by pharmacological treatments.
      • Assessing pharmacologically induced changes in spontaneous unit firing patterns in five regional rat brain slices using a planar micro-electrode array.
      • Long-term depression (LTD) in organotypic hippocampal slices grown on multielectrode arrays.
      • Ethanol Withdrawal Alters Carbachol Responses in Selective Components of the Hippocampal Network.
      • Treatment of Acute Alcohol Withdrawal and Long-Lasting Alterations in Hippocampal Neuronal Networks.
      • Cardiac myocytes derived from Nkx2.5-GFP knock-in murine embryonic stem cell: Electrophysiological differentiation and feasibility of transplantation
      • Asymmetrical Determination of Circadian Period by Synaptic Interactions in a Multi-Oscillatory System in the Suprachiasmatic Nucleus.
      • Modulation of Field Potentials Evoked in Mouse Brain Striatatal Tissue Slices Using Planar Microelectrode Array.
      • Recruitment of Paroxysmal After-Discharge in the Pyriform Cortex of Mouse Brain Amygdala Tissue Slices Following Kindling Stimulation of the Basolateral Amygdala.
      • Changes in 5-HT Receptor-Mediated Suppression of CCH-Induced Rhythmic Activity in Rat Hippocampal Slices After Chronic Fluoxetine Treatment.
      • Chronic Multichannel Recordings from Organotypic Hippocampal Slice Cultures: Evaluation of Excitotoxic Damage and Long-Term Drug Effects.
      • Serotonin Rapidly, Reversibly, and Selectively Blocks Cholinergically Driven Rhythms in Hippocampal Slices.
      • Effects of Cyclothiazide on Evoked Potentials in the Presence of Cholinegic Rhythms iin Rat Hippocampal Slices.
      • Spatial distribution of long term potentiation measured with a 64 electrode multiarray system in rat visual cortex in vitro.
      • Delayed neuronal damage in hippocampal slices: long-term recording with a multi-electrode dish
      • Patterned stimulation incorporating both gamma and theta frequencies effectively elicits LTP in rat hippocampal slices.
      • 3-D visualization of spatiotemporal patterns of rhythmic activity.
      • Prolonged perturbations in the hippocampal field response produced by brief exposure to trimethylolpropaned phosphate (TMPP).
      • Chronic multi-channel recordings from organotypic hippocampal slice cultures.
      • Evaluation of neuroactive compounds by acute multi-site recording technique in network-based hippocampal assays.
      • Network-based neuronal assays of psychoactive compounds: 1. Parallel multi-site protocols in hippocampal tri-synaptic circuits.
      • Network-based neuronal assays of psychoactive compounds: 2. Two-dimensional endogenous rhythms analysis in hippocampal slice.
      • Simultaneous multicellular calcium imaging and extracellular electrophysiological recording in rat hippocampus.
      • Multielectrode Recording of Rhythmic Oscillations in Brain Slices: A Novel Technique for Screening Psychoactive Drugs
      • Continuous two-dimensional current source density analyses of electrophysiological activity in hippocampal slices.
      • Interaction between diffuse ascending systems and rhythms in hippocampal formation.
      • Effects of psychoactive compounds on network level physiology as measured with a multielectrode array.
      • Stimulation patterns combined with endogenous rhythms reveal another level of physiology.
      • Comparison of wild-type and tottering mice with carbachol-induced oscillation in hippocampal slice.
      • Dispersal rate of the 'Beam' of synapses activated by stimulation of Schaffer-commisural fibers before and after induction of long term potentiation.
      • >Effects of positive modulators of GABA or AMPA receptors on rhythmic oscillations in hippocampal slices.
      • Origins and distribution of cholinergically induced beta rhythms in hippocampal slices.
      • Electrical stimulation modulates axonal outgrowth of neocortical neurons.
      • Electrophysiological developmental study of a rat cortical slice culture with a multi-electrode dish (MED) probe.
      • Optical imaging of intracellular calcium and neuronal activity in visuocortical slices during development: Effect of noradrenaline application.
      • Sixty-four Channel Extracellular Recording System for Slice Preparation.