Information:
Symposia/Meeting: Monday,
October 19, 6:30 - 9:00 p.m.
Location: McCormick Place
Campus, Room: S404ABCD
The goal of this symposium is to
create awareness among new
investigators and established
scientists of the diverse
applications of micro-electrode
array systems. This session will
illustrate why this system is
ideal for studying network
electrophysiology, increasing
throughput of conventional
microelectrode recordings, and
enabling researchers to quickly
and easily perform
electrophysiological studies
regardless of their scientific
background. International
speakers from industry and
academia will present their
research enabled by innovative
neuroscience research methods
with multi-electrode array
systems in a variety of
preparations. Organized by
AutoMate Scientific Inc.,
Berkeley, CA, USA and Alpha MED
Sciences Co., Ltd. Osaka, Japan.
Speakers:
"Welcome and Introduction"
Enrique G Navarrete, MD. Sales
Scientist, AutoMate Scientific.
Berkeley, CA - USA.
“The role of the VMN in sex
and food; translation from slice
to in vivo”
V. Margaret Jackson, DPhil.
Senior Principal Scientist,
Discovery Biology, Pfizer.
Groton, CT - USA.
“The network dynamics and
spontaneous activity in
dissociated rat hippocampal
culture”
Suguru N. Kudoh, PhD. Associate
Professor, Laboratory for
Neuronal Intelligence
Engineering, Department of Human
System Interaction, School of
Science and Technology, Kwansei
Gakuin University. Ikeda, Osaka
- Japan.
“Spike recordings form
acute slices of the ventral
midbrain using a multielectrode
array device:
a powerful tool for
physiological, pharmacological
and toxicological studies of the
midbrain dopaminergic system”
Dr. Nicola Berretta, PhD.
Fondazione Santa Lucia IRCCS.
Rome - Italy.
"Correlations between patch and extracellular recording methods using a
multi-electrode device (MED64)
to test the physiology and
pharmacology of transmission in
the auditory brainstem"
Ian D. Forsythe and Martin D.
Haustein. Ian D. Forsythe, PhD.
Professor, MRC Toxicology Unit,
University of Leicester.
Leicester - UK.
“Transient Choline-Mediated Depression of Synaptic Transmission in
Acutely Prepared Hippocampal
Slices”
John G. Mielke, PhD. Assistant
Professor, Department of Health
Studies and Gerontology,
University of Waterloo.
Waterloo, Ontario - Canada.
Download
Abstract
Contact:
Enrique Navarrete, MD
AutoMate Scientific Inc.
Phone: (510) 845-6283
Fax: (510) 665-3975
dregn@autom8.com
http://www.autom8.com
Rika Yamazaki
Sales and Marketing Manager
Alpha MED Sciences Co., Ltd.
Phone: 81-6-6906-2751
rika@amedsci.com
http://www.med64.com
__________________________________________________________________________________________
SFN2006 Satellite Symposium
"Recent Advances in Network Electrophysiology Using Multi-Electrode Arrays"
Atlanta Convention Center , Room B310
Monday, Oct. 16th. 6:30 – 9 p.m.
Summary:
This symposium will present an overview of the rapidly accumulating knowledge gained from using multi-electrode recordings of neuronal activity in vitro and discuss future directions of research using this technology. Presentations will focus on short and long-term properties of neuronal networks investigated in neuronal cultures and acute and cultured brain slices. The target audience for this event includes all neuroscientists who strive to get reliable, long-term, continuous recordings and two-dimensional, real-time analysis of neuronal activity.
Speakers:
1. Dr. Suguru Kudoh, Neuronics Research Group, research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology
“Reorganization of internal connectivity in dissociated neuronal culture by interaction with outer world “
2. Tim Simeone, Barrow Neurological Institute and St Joseph’s Hospital & Medical Center, Phoenix, AZ, USA
“A Planar Multielectrode Array Analysis of Resected Human Hypothalamic Hamartoma Tissue“
3. Dr. Suguru Kawato, Dept. of Biophysics and Life Sciences, Graduate School of Arts and Sciences, Univ. of Tokyo at Komaba
“Rapid modulation of hippocampal LTD by estrogen and endocrine disrupters: multielectrode analysis
4. John Mielke, National Research Council of Canada; Ontario, Canada
“Use of Multi-Electrode Arrays to Study Synaptic Activity in Cultured Hippocampal Slices “
Download Abstracts (includes contact information for speakers).
__________________________________________________________________________________________
SFN2005 Satellite Symposium
"Recent Advances in Network Electrophysiology Using Multi-Electrode Arrays"
Monday, November 14, 2005 6:30 pm - 9:00 pm
Washington Convention Center , Room 201
Summary
This symposium will present an overview of the rapidly accumulating knowledge gained from using multi-electrode recordings of neuronal activity in vitro and discuss future directions of discovery using this technology. Presentations will focus on short and long-term properties of neuronal networks investigated in neuronal cultures and acute and cultured brain slices. The target audience for this event includes all neuroscientists who strive to get reliable, long-term, continuous recordings and two-dimensional, real-time analysis of neuronal activity.
Program
6:30 PM Frank Schottler, PhD, Consultant, Alpha MED Sciences
Introduction & Opening Remarks
6:35 PM Melissa A, Harrington, PhD, Delaware State University , USA
" Stimulus-induced modulations of oscillatory neural activity in olfactory areas of snail brains recorded with a 64 electrode planar microarray"
[abstract]
7:00 PM Ying Chen, Ph.D, Eli Lilly & Co. Ltd , UK
"GABA B potentiator CGP7930 enhanced the effects of baclofen in rat hippocampal CA1 area"
[abstract]
7:25 PM Mike Ackley, Ph.D, Discovery Biology IPC 351, Pfizer Global R&D, UK
"Regional effects of opioid receptor agonists in the spinal dorsal horn"
[abstract]
7:50 PM Gong Cheng, M.D, Merck & Co., Inc. , USA
"Burst discharge induced by Kv1.5 channel antagonists in rat hippocampal slice - a study using a multi-electrode array and pClamp software"
[abstract]
8:15 PM Jun Chen, MD, Ph.D, Fourth Military Medical University , China
"Application of multi-electrode array in rat spinal cord slice: roles of excitatory and inhibitory amino acids and their receptors in mediation of network synaptic responses"
[abstract]
__________________________________________________________________________________________
SFN2004 Satellite Symposium
"Recent Advances in Network Electrophysiology Using Multi-Electrode Arrays"
Tuesday, October 26, 2004 5:30 pm - 8:00 pm
San Diego Convention Center, Room 3
Summary
This symposium will present an overview of the rapidly accumulating knowledge on multi-electrode in vitro recordings of neuronal activity and discuss future directions of discovery in this field. Presentations will focus on short and long-term properties of neuronal networks investigated in acute and cultured brain slices. The target audience for this event includes all neuroscientists who strive to get reliable, long-term, continuous recordings and two-dimensional, real-time analysis of neuronal activity.
Program
5:30 Daniel Chun, Multi-Electrode System, Inc, USA
Recent Applications using Multi-electrode arrays.
[see abstract]
6:10 Natalia Bastrikova, NIH, USA
Long-Term Depression (LTD) in Organotypic Hippocampal Slice Grown on Multi-Electrode Arrays.
[see abstract]
6:50 Yousheng Jia, University of California, Los Angeles, Tensor Biosciences, USA
Obesity Drug Assay Using Arcuate Nucleus Slice.
[see abstract]
7:30 Jun Chen, Forth Military Medical University, China
Properties of Network Synaptic Transmission in Spinal Cord Dorsal Horn of Postnatal Rats.
[see abstract]
__________________________________________________________________________________________
SFN2003 Satellite Symposium
Recent Advances in Network Electrophysiology Using Multi-Electrode Arrays
Monday, November 10, 2003 6:30 pm - 9:00 pm
Morial Convention Center, Room: 253 - 254
Alpha MED Sciences Co., Ltd. is a subsidiary of Panasonic dedicated to multi-electrode physiology.
This symposium will present an overview of the rapidly accumulating knowledge on multi-electrode in vitro recordings of neuronal activity and discuss future directions of discovery in this field. Presentations will focus on short and long-term properties of neuronal networks investigated in acute and cultured brain slices. The target audience for this event includes all neuroscientists who strive to get reliable, long-term, continuous recordings and two-dimensional, real-time analysis of neuronal activity.
Program
6:30 Larry P. Gonzalez, University of Oklahoma Health Sciences Center
Multi-electrode Arrays Allow Determination of Regional Hippocampal Differences in Chronic Ethanol Effects.
Prof Gonzalez will discuss their use of the MED64 probe with an acute hippocampal slice preparation to
investigate the effects of chronic ethanol treatment and withdrawal. Studies to be presented examine evoked responses in hippocampal areas CA1 and CA3 in the presence and absence of carbachol and demonstrate a significant reduction in carbachol-induced paired-pulse facilitation during ethanol withdrawal that is limited to area CA1.
[see Abstract (PDF 262 KB)]
6:55 Suguru Kawato, University of Tokyo
Rapid modulation of hippocampal neuronal plasticity by brain estrogen and endocrine disrupters: an electrophysiological analysis.
Prof Kawato will discuss his recent discovery of the acute effect of neurosteroids on learning and memory. The acute actions of estradiol, BPA and DES were analyzed by measuring the long-term potentiation (LTP) induced upon titanic stimulation of the CA1 pyramidal neurons in rat hippocampal slices. Estradiol and DES enhanced LTP and these effects were suppressed by ERa inhibitor ICI 182,780. BPA, on the other hand, did not affect LTP. These findings suggest that EDs do have significant disrupting actions on learning and memory, and that their enhancing/suppressive effects are depending on individual EDs.
[see Abstract (PDF 91 KB)]
7:20 John Rossi III, Naval Health Research Center, Ohio
Use of a Planar Microelectrode Array System for Evaluation of Changes in Potentials Evoked in Acute Brain Slices from Bluegill Sunfish (Lepomis Macrochirus), Induced by Neurobehavioral Toxicants in Drinking Water.
Dr. Rossi will discuss their development of more flexible detection instrument that can respond over a wide range of toxicant types and concentrations. The system is currently based on acute slices taken from the optic tectum of the bluegill sunfish. The fish slice was chosen because of its relative insensitivity to temperature changes when compared to slices taken from rodent brain. Additionally, the optic tectum slice provides an astonishingly rich subset of receptors to neurotransmitters and neuromodulators.
[see Abstract (PDF 119KB)]
7:45 Michael Krause, Tensor Biosciences, California
Accelerating Electrophysiology Using Higher-Throughput Multielectrode Arrays.
Dr. Krause will introduce Tensor's Brain-on-a-chip assay technology. Long-term effects of compounds can be studied using brain tissue cultured directly on the MED probe. This assay takes advantage of functional synaptic physiology in these cultured slices and the fact that the same pathway can be recorded over many days. He will also introduce a recently developed multiple Multielectrode Array system. It uses a time-sharing algorithm to simultaneously acquire and process data from 4 or more slice preparations. Applications of this approach in LTP experiments will be discussed.
[see Abstract (PDF 77KB)]
8:10 Nathan R. Wilson, Picower Center for Learning and Memory, MIT
Exploring Synaptic Interactions and Network Plasticity with Multi-Electrode Devices.
Dr. Wilson will discuss implications and applications of MEA's unique potential for inducing learning across networks of cells via programmable spatiotemporal stimulation. The input-output relationship of neuronal networks is established through the coordinated refinement of synaptic connections. Observing synaptic refinement electrophysiologically requires tools for monitoring currents at the synaptic level while also triggering controlled communication from identifiable neighboring cells. Multi-electrode arrays are ideally suited for this purpose in that they allow for the stimulation of multiple sites in repeatable patterns with high temporal precision.
[see Abstract (PDF 185 KB)]
8:35 Ole Paulsen, University Laboratory of Physiology, Oxford
Network Oscillations Studied Using Planar Multielectrode Arrays.
Dr. Paulsen will discuss their recent results using the MED64 system to record and analyse drug-induced network oscillations in acute hippocampal slices. The powerful combination of the MED64 array with voltage-sensitive dye recording and patch-clamp recordings will be highlighted.
[see Abstract (PDF 90 KB)]
Abstracts from the 1st Network Physiology Symposium
Nov. 2002, Orlando Florida (PDF 283 KB)
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