MED64 multi-electrode array system
A complete, user-friendly solution for in-vitro electrophysiology
based on planar microelectrode technology.
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MED64 Publications

This is a listing of all the published journal articles that report using the MED64 system. Let us know if you notice we have missed any.

Application list

Acute slices                                                         
  Hippocampus  
  Cortex
  Midbrain (Substantia nigra, Superior colliculus)
  Hypothalamus, SCN
  Brainstem

Slice cultures
  Hippocampus
  Cerebellum, Cortex, SCN    

Neuron cultures

Retina

Cardiac tissue    
Cardiac myocyte cultures 

Smooth muscle  

Cell line

Chronological list

 2009 2008, 2007, 2006, 2005 , 2004 , 2003 , 2002 , 2001 , 2000 , 1999 , 1998

2010 Journals

Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs.                                     NEW!
Otsuji TG, Minami I, Kurose Y, Yamauchi K, Tada M, Nakatsuji N.
Stem Cell Res. 2010 Feb 6

2009 Journals

The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells.
 Yokoo N, Baba S, Kaichi S, Niwa A, Mima T, Doi H, Yamanaka S, Nakahata T, Heike T.
Biochem Biophys Res Commun. 2009 Sep 25;387(3):482-8.     

IIn vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes
. Tanaka T, Tohyama S, Murata M, Nomura F, Kaneko T, Chen H, Hattori F, Egashira T, Seki T, Ohno Y, Koshimizu U, Yuasa S, Ogawa S, Yamanaka S, Yasuda K, Fukuda K.
Biochem Biophys Res Commun. 2009 Aug 7;385(4):497-502.     


Effects of bupivacaine and ropivacaine on field potential in rat hippocampal slices
Yi JW, Lee BJ, Kim DO, Park SW, Choi YK, Chang HK, Kim CJ, Park JH.
Br J Anaesth. 2009 May;102(5):673-9.     

Differential effects of long and short train theta burst stimulation on LTP induction in rat anterior cingulate cortex slices: multi-electrode array recordings.
He Y, Liu MG, Gong KR, Chen
J. Neurosci Bull. 2009 Oct;25(5):309-18.  

Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording.
Zhao XY, Liu MG, Yuan DL, Wang Y, He Y, Wang DD, Chen XF, Zhang FK, Li H, He XS, Chen J.
Mol Pain. 2009 Sep 22;5:55.   

Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.
Hawasli AH, Koovakkattu D, Hayashi K, Anderson AE, Powell CM, Sinton CM, Bibb JA, Cooper DC.
PLoS One. 2009 Jun 4;4(6):e5808  


Microelectrode array evaluation of gut pacemaker activity in wild-type and W/W(v) mice.  
Nakayama S, Ohishi R, Sawamura K, Watanabe K, Hirose K.
Biosens Bioelectron. 2009 Jun 10.

Effects of Aldosterone on Cx43 Gap Junction Expression in Neonatal Rat Cultured Cardiomyocytes.
Suzuki S, Ohkusa T, Sato T, Yoshida M, Yasui K, Miwa K, Lee JK, Yano M, Kodama I, Matsuzaki M.
Circ J. 2009 Jun 16. [Epub ahead of print]

Neuronal and network activity in networks of cultured spinal motor neurons
Zhang HM, Robinson N, Gómez-Curet I, Wang W, Harrington MA.
Neuroreport. 2009 Jun 17;20(9):849-54.

Detection of localized retinal malfunction in retinal degeneration model using a multielectrode array system.
Homma K, Osakada F, Hirami Y, Jin ZB, Mandai M, Takahashi M.                     
J Neurosci Res
. 2009 Jul;87(9):2175-82.                                                                                                       

Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells.                                 
Kawashima A, Harada T, Kami H, Yano T, Imada K, Mizuguchi K.
J Nutr Biochem. 2009 Apr 13.

Maintaining network activity in submerged hippocampal slices: importance of oxygen supply.
Hájos N, Ellender TJ, Zemankovics R, Mann EO, Exley R, Cragg SJ, Freund TF, Paulsen O.
Eur J Neurosci
. 2009 Jan;29(2):319-27

 

2008 Journals

Kent J, Meredith AL.
PLoS ONE . 2008;3(12):e3884. Epub 2008 Dec 8.
Perception. 2008;37(3):401-7

Paracrine factors of vascular endothelial cells facilitate cardiomyocyte differentiation of mouse embryonic stem cells.
Kado M, Lee JK, Hidaka K, Miwa K, Murohara T, Kasai K, Saga S, Morisaki T, Ueda Y, Kodama I.
Biochem Biophys Res Commun
. 2008 Dec 12;377(2):413-8. Epub 2008 Oct 18.

Programmed alterations in hypothalamic neuronal orexigenic responses to ghrelin following gestational nutrient restriction
Jia YS, Nguyen T, Desai M, Ross MG .
REPRODUCTIVE SCIENCES   2008 Sep;15(7):702-9. Epub 2008 Jun 18.

 
J Neurosci. 2008 Sep 10;28(37):9309-18.
 
Lytton WW, Orman R, Stewart M.
Perception. 2008;37(3):401-7

On the role of calcium and potassium currents in circadian modulation of firing rate in rat suprachiasmatic nucleus neurons: multielectrode dish analysis.
Kononenko NI, Honma S, Dudek FE, Honma K.
Neurosci Res. 2008 Sep;62(1):51-7. Epub 2008 Jun 17

Role of RhoA in activity-dependent cortical axon branching.
Ohnami S, Endo M, Hirai S, Uesaka N, Hatanaka Y, Yamashita T, Yamamoto N.
J Neurosci. 2008 Sep 10;28(37):9117-21

Factors that regulate KiSS1 gene expression in the hippocampus.
Arai AC, Orwig N                                
Brain Res.  2008 Sep.19
 
Hosokawa C, Kudoh SN, Kiyohara A, Taguchi T                                
Neuroreport
. 2008 May 7;19(7):771-5

Time-Dependent Block of Ultra-Rapid Delayed Rectifier K+ Currents by Aconitine, a Potent Cardiotoxin, in Heart-Derived H9c2 Myoblasts and in Neonatal Rat Ventricular Myocytes .
Ya-Jean Wang, Bing-Shuo Chen, Ming-Wei Lin, An-An Lin, Hsung Peng, Ruey J. Sung, and Sheng-Nan Wu.                                  
ToxSci Advance Access published on September 8, 2008. 

On the mechanisms of arrhythmias in the myocardium of mXinalpha-deficient murine left atrial-pulmonary veins.
Lai YJ, Huang EY, Yeh HI,Chen YL, Lin JJ, Lin CI.                                  
Life Sci. 2008 Aug 15;83(7-8):272-83.

Local axon collaterals of area CA1 support spread of epileptiform discharges within CA1, but propagation is unidirectional.
Orman R,Von Gizycki H,Lytton WW,Stewart M.                                  
Hippocampus 2008 Jun 11.

Prelimbic and infralimbic prefrontal cortex interact during fast  network oscillations
Van Aerde KI, Heistek TS, Mansvelder HD.                                  
PLoS ONE. 2008 Jul 16;3(7):e2725.

Spontaneous activity in Purkinje cells : Multi-electrode recording from organotypic cerebellar slice cultures.
Kessler M, Kiliman B, Humes C, Arai AC.
Brain Research (2008 May 1.)

Synapse elimination accompanies functional plasticity in hippocampal neurons.
Bastrikova N, Gardner GA, Reece JM, Jeromin A, Dudek SM.
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3123-7. Epub 2008 Feb 19.

Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PSldE9 mouse model of Alzheimer's disease
Yasuaki Goto, Tetsuhiro Niidome, Haruyuki Hongo, Akinori Akaike, Takeshi Kihara, Hachiro Sugimoto
Eur J Pharmacol. 2008 Mar 31;583(1):84-91 . Epub 2008 Feb 5.

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2007 Journals

Synaptic activity and triphenyltetrazolium chloride metabolism are correlated after oxygen-glucose deprivation in acute, but not cultured, hippocampal slices
John G. Mielke, Tanya Comas, Tarun Ahuja, Edward Preston, Geoffrey A.R. Measing
Brain Res. 2007 Oct 24;1176:113-23. Epub 2007 Aug 22.

T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca2+ channel blockers.
Horiba M, Muto T, Ueda N, Opthof T, Miwa K, Hojo M, Lee JK, Kamiya K, Kodama I, Yasui K.
Life Sci
. 2008 Mar 12;82(11-12):554-60. Epub 2007 Dec 4

Small-world network topology of hippocampal neuronal network is lost, in and in vitro glutamate injury model of epilepsy
Kalyan V. Srinivas, Rishabh Jain, Subit Saurav and Sujit K.Sikdar.
European Jounral of Neuroscience (2007), Vol. 25, 3276-3286

Biomodeling System-Interaction Between Living Neuronal Networks and the Outer World
Suguru N. Kudoh, Chie Hosokawa, Ai Kiyohara, Takahisa Taguchi, and Isao Hayashi
Journal of Robotics and Mechatronics 2007,  Vol.19 No.5, 559-600

Local Production of Sex Hormones and Their Modulation of Hippocampal Synaptic Plasticity.
Ishii H., Tsurugizawa T., Ogiue-Ikeda M., Asashima M., Mukai H., Murakami G., Hojo Y., Kimoto T. and Kawato S.
The Neuroscientist (2007) 13, 323-334

Memantine Inhibits ATP-Dependent K+ Conductances in Dopamine Neurons of the Rat Substantia Nigra Pars Compacta
Michela Giustizieri, Maria Letizia Cucchiaroni, Ezia Guatteo, Giorgio Bernardi, Nicola B.Mercuiri, and Nicola Berretta
Pharmacol Exp Ther.2007 Aug;322(2):721-9.

Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation
Hawasli AH, Benavides DR, Nguyen C, Kansy JW, Hayashi K, Chambon P, Greengard P, Powell CM, Cooper DC, Bibb JA
Nat Neurosci. 2007 Jul;10(7):880-6


Interplay between laminar specificity and activity-dependent mechanism of thalamocortical axon branching.
Uesaka N, Hayano Y, Yamada A, Yamamoto N.
J Neurosci. 2007 May 9;27(19):5215-23.


Rapid Modulation of Long-term Depression and spinogenesis via Synaptic Estrogen Receptors in Hippocampal Prinsipal Neurons
Mukai H., Tsurugizawa T., Murakami G., Kominami S., Ishii H., Ogiue-Ikeda M., Takata N., Tanabe N., Furukawa A., Hojo Y., Ooishi Y., Morrison J.H., Janssen W.G.M., Rose J.A., Chambon P., Kato S., Izumi S., Yamazaki T., Kimoto T. and Kawato S.
J. Neurochem. 2007 Feb, 100, 950-967

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2006 Journals

Local neurosteroid production in the hippocampus: influence for synaptic plasticity of memory.
Mukai H., Tsurugizawa T., Ogiue-Ikeda M., Murakami G., Hojo Y., Ishii H., Kimoto T., Kawato S.
Neuroendocrinology (2006) 84, 255-263

Pacemaker phase shift in the absence of neural activity in guinea-pig stomach: a microelectrode array study
Shinsuke Nakayama, Ken Shimono, Hong-Nian Liu, Hideyasu Jiko, Noburu Katayama, Tadao Tomita and Kazunori Goto
J Physiol., 2006, 576.3 pp 727-738

Longitudinal study of the effects of a high-fat diet on glucose regulation, hippocampal function, and cerebral insulin sensitivity in C57BL/6 mice
Mielke JG, Nicolitch K, Avellaneda V, Earlam K, Ahuja T, Mealing G, Messier C.
Behav Brain Res. 2006 Dec 15;175(2):374-82. Epub 2006 Nov 1.

Electrical coupling of cardiomyocyte sheets occurs rapidly via functional gap junction formation. Biomaterials
Haraguchi Y, Shimizu T, Yamato M, Kikuchi A, Okano T.
Biomaterials.2006 Sep;27(27):4765-74. Epub 2006 Jun 5

Effects of Lamotrigine on field potentials, propagation, and long-term potentiation in rat prefrontal cortex in multi-electrode recording
Chin-Wei Huang , Yi-Jung Hsieh, Jing-Jane Tsai, Chao-Ching Huang
Journal of Neuroscience Research, volume 83, Issue6, Pages 1141-1150

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2005 Journals

Tissue cardiomyoplasty using bioengineered contractile cardiomyocyte sheets to repair damaged myocardium: their integration with recipient myocardium.
Miyagawa S, Sawa Y, Sakaida S, Taketani S,Kondoh H, Memon IA, Imanishi Y, Shimizu T, Okano T, Matsuda H.
Transplantation. 2005 Dec 15;80(11):1586-95.

Zonisamide at clinically relevant concentrations inhibits field EPSP but not presynaptic fiber volley in rat frontal cortex
Huang CW, Ueno S, Okada M, Kaneko S
Epilepsy Res 2005 Oct-Nov;67(1-2):51-60
 

Protective role of hydrogen peroxide in oxygen-deprived dopaminergic neurones of the rat substantia nigra.
Geracitano R, Tozzi A, Berretta N, Florenzano F, Guatteo E, Viscomi MT, Chiolo B, Molinari M, Bernardi G, Mercuri NB
J Physiol 2005 Oct 1;568(Pt 1):97-110.

Nonphotic entrainment of the circadian body temperature rhythm by the selective ORL1 receptor agonist W-212393 in rats.
Teshima K, Minoguchi M, Tounai S, Ashimori A, Eguchi J, Allen CN, Shibata S
Br J Pharmacol 2005 Sep;146(1):33-40.

Investigating neuronal activity with planar microelectrode arrays: achievements and new perspectives.
Morin FO, Takamura Y, Tamiya E
J Biosci Bioeng 2005 Aug;100(2):131-43

Synchronized retinal oscillations encode essential information for escape behavior in frogs.
Ishikane H, Gangi M, Honda S, Tachibana M
Nat Neurosci 2005, 8:1087-95

Dephosphorylation and internalization of cell adhesion molecule L1 induced by theta burst stimulation in rat hippocampus.
Itoh K, Shimono K, Lemmon V
Mol Cell Neurosci 2005 Jun;29(2):245-9

Serotonergic modulation of carbachol-induced rhythmic activity in hippocampal slices.
Krause M, Jia Y
Neuropharmacology 2005 Mar;48(3):381-90.

Temporal properties of retinal ganglion cell responses to local transretinal current stimuli in the frog retina.
Li L, Hayashida Y, Yagi T
Vision Res 2005 Jan;45(2):263-73

Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro.
Mann EO, Suckling JM, Hajos N, Greenfield SA, Paulsen O.
Neuron. 2005 Jan 6;45(1):105-17

Activity dependence of cortical axon branch formation: a morphological and electrophysiological study using organotypic slice cultures.
Uesaka N, Hirai S, Maruyama T, Ruthazer ES, Yamamoto N
J Neurosci 2005 Jan 5;25(1):1-9.

Hippocampal gamma-frequency oscillations: from interneurones to pyramidal cells, and back.
Mann EO, Radcliffe CA, Paulsen O
J Physiol 2005 Jan 1;562(Pt 1):55-63.

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2004 Journals

Conduction abnormality in gap junction protein connexin45-deficient embryonic stem cell-derived cardiac myocytes.
Egashira K, Nishii K, Nakamura K, Kumai M, Morimoto S, Shibata Y
Anat Rec 2004 Oct;280A(2):973-9.

Spike Timing of Distinct Types of GABAergic Interneuron during Hippocampal Gamma Oscillations In Vitro
Hajos N, Palhalmi J, Mann EO, Nemeth B, Paulsen O, Freund TF
J Neurosci, October 13, 2004, 24(41):9127-9137

Protein processing and releases of neuregulin-1 are regulated in an activity-dependent manner.
O zaki M, Itoh K, Miyakawa Y, Kishida H, Hashikawa T
J Neurochem 2004 Oct;91(1):176-88

Protein kinase associated with gating and closing transmission mechanisms in temporoammonic pathway.
Okada M, Zhu G, Yoshida S, Hirose S, Kaneko S
Neuropharmacology 2004 Sep;47(4):485-504.

Rapid electrical stimulation of contraction modulates gap junction protein in neonatal rat cultured cardiomyocytes: involvement of mitogen-activated protein kinases and effects of angiotensin II-receptor antagonist.
Inoue N, Ohkusa T, Nao T, Lee JK, Matsumoto T, Hisamatsu Y, Satoh T, Yano M, Yasui K, Kodama I, Matsuzaki M
J Am Coll Cardiol 2004 Aug 18;44(4):914-22.

Electrophysiological characteristic of corticoaccumbens synapses in rat mesolimbic system reconstructed using organotypic slice cultures.
Maeda T, Fukazawa Y, Shimizu N, Ozaki M, Yamamoto H, Kishioka S
Brain Research 2004 Jul 23;1015(1-2):34-40.

Effects of GABA and bicuculline on the electrical activity of rat olfactory placode neurons derived at E13.5 and cultured for 1 week on multi-electrode dishes.
Suyama K, Daikoku S, Funabashi T, Kimura F
Endocrine J 2004 Apr;51(2):171-6.

Operation of spatiotemporal patterns stored in living neuronal networks cultured on a microelectrode array.
Kudoh SN, Taguchi T
J Advanced Computational Intelligence. 2004; 8(2): 100-7.

Diversity in the circadian periods of single neurons of the rat
suprachiasmatic nucleus depends on nuclear structure and intrinsic period

Sato Honma, Wataru Nakamura, Tetsuo Shirakawa, Ken-ichi Honma
Neuroscience Letters , 358 (2004) 173ˇ76

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2003 Journals

A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation.
 Thomas-Crusells J, Vieira A, Saarma M, Rivera C
 J Neurosci Methods 2003 May 30;125(1-2):159-66.

Synaptic plasticity preserved with arachidonic acid diet in aged rats.
Susumu Kotani et al.
Neuroscience Research 46 (2003) 453/461

Long-term recording of LTP in cultured hippocampal slices.
Shimono K, Baudry M, Ho L, Taketani M. and Lynch G.
Neural Plasticity. 2002;9(4):249-54. (late publication)

Activity-Evoked Capacitative Ca2+ Entry: Implications in Synaptic Plasticity
Atsushi Baba, Takuya Yasui, Shigeyoshi Fujisawa, Ryuji X. Yamada, Maki K. Yamada, Nobuyoshi Nishiyama, Norio Matsuki, and Yuji Ikegaya
Journal of Neuroscience, August 27, 2003, 23(21):7737-7741

Circadian dynamics of cytosolic and nuclear Ca 2+ in single suprachiasmatic nucleus neurons.
Ikeda M, Sugiyama T, Wallace CS, Gompf HS, Yoshioka T, Miyawaki A, Allen CN
Neuron 2003, April24, 38: 253-263

A biosensing system based on extracellular potential recording of ligand-gated ion channel function overexpressed in insect cells.
Haruyama T, Bongsebandhu-Phubhakdi S, Nakamura I, Mottershead D, Keinanen K, Kobatake E, Aizawa M
Analytical Chemistry 2003 Feb 15;75(4):918-21 .

Age-dependent modulation of hippocampal excitability by KCNQ-channels.
Okada M, Zhu G, Hirose S, Ito KI, Murakami T, Wakui M, Kaneko S.
Epilepsy Research 2003 Feb;53(1-2):81-94

Mossy fibre synaptic NMDA receptors trigger non-Hebbian long-term potentiation at entorhino-CA3 synapses in the rat.
Tsukamoto M, Yasui T, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y
Journal of  Physiology 2003, Feb 1;546(Pt 3):665-75.

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2002 Journals

Impaired M-current and neuronal excitability.
Okada M, Wada K, Kamata A, Murakami T, Zhu G, Kaneko S.
Epilepsia 2002;43 Suppl 9:36-8

Chronic multichannel recordings from organotypic hippocampal slice cultures: protection from excitotoxic effects of NMDA by noncompetitive NMDA antagonists
Ken Shimono a,*, Michel Baudry b, Victor Panchenko a, Makoto Taketani a
Journal of Neuroscience Methods 120 (2002) 193-202

Chronic exposure to trichloroethylene affects neuronal plasticity in rat hippocampal slices
Lilo Altmann a, Peter Welge b, Thomas Mensing b, Hellmuth Lilienthal a, Bruno Voss b and Michael Wilhelm b, c
Environmental Toxicology and Pharmacology, Volume 12, Issue 3, October 2002, Pages 157-167

Asymmetrical distribution of the Schaffer projections within the apical dendrites of hippocampal field CA1
Shimono K, Kubota D, Bruhcer F, Takenati M, Lynchi G.
Brain Research 2002 Sep 20; 950 (1-2): 279

A simple exploratory algorithm for the accurate and fast detection of spontaneous synaptic events.
Kudoh SN, Taguchi T.
Biosensors and Bioelectronics 2002 Sep;17(9):773-82.

Clock mutation lengthens the circadian period without damping rhythms in individual SCN neurons
Wataru Nakamura 1, 2, Sato Honma 1, Tetsuo Shirakawa 2 & Ken-ichi Honma 1 (2002)
Nature Neuroscience, 5 399-400

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2001 Journals

Regional pacemakers composed of multiple oscillator neurons in the rat suprachiasmatic nucleus.
Nakamura W. et. al. (2001)
European Journal of Neuroscience

Polysynaptic excitatory pathways induce heterosynaptic depression in the rat auditory cortex
Ryong-Moon Shin et. al. (2001)
Neuroscience Research

Immortalized Gonadotropin-Releasing Hormone Neurons (GT1-7 Cells) Exhibit Synchronous Bursts of Action Potentials
Toshiya Funabashi et. al. (2001)
Neuroendocrinology

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2000 Journals

Selective suppression of horizontal propagation in rat visual cortex by norepinephrine
Masayuki Kobayashi et. al. (2000)
European Journal of Neuroscience

Origins and distribution of cholinergically induced beta rhythms in hippocampal slices.
Ken Shimono et. al (2000),
J. Neuroscience

Synchronization of circadian firing rhythms in cultured rat suprachiasmatic neurons
Tetsuo Shirakawa et. al. (2000)
European J. Neuroscience

Dysfunction of M-channel enhances propagation of neuronal excitability in rat hippocampus monitored by multielectrode dish and microdialysis systems
Gang Zhu et. al. (2000)
Neuroscience Letters


Synaptic communication of cellular oscillations in the rat suprachiasmatic neurons
Sato Honma et. al. (2000)
Neuroscience Letters

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1999 Journals

A new planar multielectrode array for extracellular recording: application to hippocampal acute slice
Hiroaki Oka et. al. (1999)
J. Neuroscience Methods

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1998 Journals

Circadian periods of single suprachiasmatic neurons in rats
Sato Honma et. al. (1998)
Neuroscience Letters

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