Cardiac Myocyte Cultures

A novel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval.       NEW!
Yamazaki K, Hihara T, Taniguchi T, Kohmura N, Yoshinaga T, Ito M, Sawada K.
Toxicol In Vitro. 2011 Dec 14

Creation of mouse embryonic stem cell-derived cardiac cell sheets. 
Matsuura K, Masuda S, Haraguchi Y, Yasuda N, Shimizu T, Hagiwara N, Zandstra PW, Okano T.
Biomaterials. 2011 Oct;32(30):7355-62. Epub 2011 Jul 31.


Apple procyanidins induce hyperpolarization of rat aorta endothelial cells via activation of K(+) channels.
Byun EB, Korematsu S, Ishikawa T, Nishizuka T, Ohshima S, Kanda T, Matsui T.
J Nutr Biochem. 2011 May 2. [Epub ahead of print] 


Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-a.    
Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada M, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R, Mummery CL, Nakatsuji N, Yamanaka S, Nakao K, Yamashita JK.
PLoS One. 2011 Feb 22;6(2):e16734.

Usefulness of field potential as a marker of embryonic stem cell-derived cardiomyocytes, and endpoint analysis of embryonic stem cell test.
Koseki N, Deguchi J, Yamada T, Funabashi H, Seki T.
J Toxicol Sci. 2010 Dec;35(6):899-909.


Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.
Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T.
Cardiovasc Res. 2010 Nov 1;88(2):314-23


Usefulness of field potential as a marker of embryonic stem cell-derived cardiomyocytes, and endpoint analysis of embryonic stem cell test.
Koseki N, Deguchi J, Yamada T, Funabashi H, Seki T.
J Toxicol Sci. 2010;35(6):899-909


Improvement of the embryonic stem cell test endpoint analysis by use of field potential detection.
Koseki N, Deguchi J, Yamada T, Funabashi H, Seki T.
J Toxicol Sci. 2010;35(5):619-29.


Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs.                                    
Otsuji TG, Minami I, Kurose Y, Yamauchi K, Tada M, Nakatsuji N.
Stem Cell Res. 2010 Feb 6.


The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells.
Yokoo N, Baba S, Kaichi S, Niwa A, Mima T, Doi H, Yamanaka S, Nakahata T, Heike T.
Biochem Biophys Res Commun. 2009 Sep.     


In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes
Tanaka T, Tohyama S, Murata M, Nomura F, Kaneko T, Chen H, Hattori F, Egashira T, Seki T, Ohno Y, Koshimizu U, Yuasa S, Ogawa S, Yamanaka S, Yasuda K, Fukuda K.
Biochem Biophys Res Commun. 2009 Aug 7;385(4):497-502.  


Effects of Aldosterone on Cx43 Gap Junction Expression in Neonatal Rat Cultured Cardiomyocytes.
Suzuki S, Ohkusa T, Sato T, Yoshida M, Yasui K, Miwa K, Lee JK, Yano M, Kodama I, Matsuzaki M.
Circ J. 2009 Jun 16. [Epub ahead of print]


Application of a cell sheet-polymer film complex with temperature sensitivity for increased mechanical strength and cell alignment capability.
Fujita H, Shimizu K, Nagamori E.
Biotechnol Bioeng. 2009 Jun 1;103(2):370-7.


Paracrine factors of vascular endothelial cells facilitate cardiomyocyte differentiation of mouse embryonic stem cells.
Kado M, Lee JK, Hidaka K, Miwa K, Murohara T, Kasai K, Saga S, Morisaki T, Ueda Y, Kodama I.
Biochem Biophys Res Commun. 2008 Dec 12;377(2):413-8. Epub 2008 Oct 18.

T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca2+ channel blockers.
Horiba M, Muto T, Ueda N, Opthof T, Miwa K, Hojo M, Lee JK, Kamiya K.
Life Sci. 2008 Mar 12;82(11-12):554-60. Epub 2007 Dec.


Construction of multi-layered cardiomyocyte sheets using magnetite nanoparticles and magnetic force.
Shimizu K, Ito A, Lee JK, Yoshida T, Miwa K, Ishiguro H, Numaguchi Y, Murohara T, Kodama I, Honda H.
Biotechnol Bioeng. 2007 Mar 1;96(4):803.


lectrical coupling of cardiomyocyte sheets occurs rapidly via functional gap junction formation. Biomaterials
Haraguchi Y, Shimizu T, Yamato M, Kikuchi A, Okano T.
Biomaterials.2006 Sep;27(27):4765-74. Epub 2006 Jun 5.

Tissue cardiomyoplasty using bioengineered contractile cardiomyocyte sheets to repair damaged myocardium: their integration with recipient
Miyagawa S, Sawa Y, Sakaida S, Taketani S,Kondoh H, Memon IA, Imanishi Y, Shimizu T, Okano T, Matsuda H.
Transplantation. 2005 Dec 15;80(11):1586-95

Conduction abnormality in gap junction protein connexin45-deficient embryonic stem cell-derived cardiac myocytes.
Egashira K, Nishii K, Nakamura K.
Anat Rec 2004 Oct;280A(2):973-9.

Rapid electrical stimulation of contraction modulates gap junction protein in neonatal rat cultured cardiomyocytes: involvement of mitogen-activated protein kinases and effects of angiotensin II-receptor antagonist.
Inoue N, Ohkusa T, Nao T, Lee JK, Matsumoto T, Hisamatsu Y, Satoh T, Yano M, Yasui K, Kodama I, Matsuzaki M.
J Am Coll Cardiol 2004 Aug 18;44(4):914-22.