Cardiomyocyte signal waveforms [bottom, highlighted in light green], beat frequency [middle], and interspike interval.
[Left] Extracted cardiomyocyte signal. [Right] Time between peaks (Field potential duration) of the extracted waveforms is calculated using the “Time of Amplitude Max to Max” measure.
The average for each phase (defined by yellow bars in the top chart) is computed and graphed.
Available measurement protocol
- Time of Amplitude Minimum (or Max) to Minimum (or Max)
- Time of Amplitude Minimum (or Maximum)
- Time from Minimum (Max) to Half-minimum (Max)
- Amplitude (Minimum, Maximum, Peak to Peak)
- Slope (10-90%, 10-40%, Linear fit)
- Absolute Area
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Features
- Ideal for recording and analysis of cardiomyoyte preparations, including iPS/ES cell-derived cardiomyocytes, primary myocyte cultures, and acute heart tissue.
- Signals are recorded at any of 64 channels according to user-defined acquisition parameters.
- Acquisition parameters and channels for analysis are selected easily in a simple control panel.
- Carciomyocyte signals are automatically extracted according to user-defined thresholds and analyzed for beat frequencies and inter-spike intervals.
- Multiple types of slope, amplitude, time, and area measurements can be performed automatically on extracted signals.
- Field potential duration (FPD) can be also measured from extracted waveforms for studying QT prolongation with the “Time of Amplitude Minimum (or Max) to Minimum (or Max)” measure
- Averages and standard deviations for the beat frequencies, inter-spike intervals, and waveform analyses on all 64 channels can be automatically computed and graphed for each user-defined phase of an experiment. Dose-response curves can thus be easily constructed.
Data Output
Raw data can be exported in binary or ASCII text file (csv) format.
Extracted spikes and all measurement charts can be saved as “csv” formatted text files.
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