Experiment-based Applications

Synaptic Plasticity

Single Unit Activity

Rhythmic Activity

Muscle Propagation
and Pacing

QT Prolongation

Pharmacology and
Drug Testing

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Preparation-Based Applications

PREPARATION BASED APPLICATIONS

Slice Cultures –Cerebellum–

Publications for this application

Example: Spontaneous activities from cultured cerebellum 

[Left, Center] Cerebellar slice cultured on a MED probe (left). The slice was prepared from 10-day old rat and cultured for 10 days on a membrane, then transferred to the MED probe. The diagram (center) shows the microanatomy with respect to the electrode arrangement.
 
[Right] Spontaneous activity recorded from 2 different channels. The recording sites and corresponding channels within the slice are indicated in the schematic diagram and image above.
Single units can be studied for extended periods of time (up to 2 weeks).

The synaptic physiology and pharmacology of cerebellar neurons can be evaluated over several weeks. Cultures on MED64 probes can be viable for several months.

Courtesy of A.Arai at Southern Illinois University