Experiment-based Applications

Synaptic Plasticity

Single Unit Activity

Rhythmic Activity

Muscle Propagation
and Pacing

QT Prolongation

Pharmacology and
Drug Testing

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Preparation-Based Applications

PREPARATION BASED APPLICATIONS

Acute Slices –Suprachiasmatic Nucleus (SCN)–

Publications for this application

Example : Drug effects on SCN neurons

[Left] Micrograph of a rat SCN slice on MED-P515A probe.
(150μm inter-polar distance)

[Right] Spontaneous activity of SCN neurons recorded at the electrode marked in red. The activity decreased in the presence of serotonin.

[Bottom] Serotonin reduces the rate of spontaneous firing in a dose-dependent manner. The rate of spontaneous activity seen in the baseline period (approximately 4 Hz) decreased noticeably as the serotonin concentration was increased from 1 to 10µM. Partial recovery was observed after washing out the drug.