MED64 Application Specialists
A complete, easy-to-use Multi-Electrode Array based solution for
advanced in vitro multi-site extracellular electrophysiology.
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Applications
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  Synaptic Activity
  Biological Rythms
  Pharmacology and Drug Testing
  Unit and Network Activity
  Muscle Propagation and Pacing
  Combining with Other Equipment

  Preparation Based Applications

MED64 Applications

The MED64 system is well suited for experiments using acute slices as well as slice (and cell) cultures. The low impedance of of Pt. black electrodees (7-10 khom at 1 kHz tycpially) enables to acquire several types of signals (from slow-wave to spike signals) easily.

Multi-electrode arrays are widely used in studies of the central (CNS: e.g. Cortex, Hippocampus; retina, Suprachiasmatic Nucleus, SCN) and peripheral (PNS: e.g. Dorsal Root Ganglion, DRG) nervous system, as well as myocardial and other excitable tissue (e.g. smooth muscle). Extracellular stimulation and recording can be combined with patch clamping, microscopic visualization, or other methods (e.g. Ca ++ imaging) used to examine relationships between structure and function.

Experimental Examples

1) Studies on Synaptic Activity
LTP | CSD

2) Studies of Biological Rhythms

Spontaneous Rhythmic Activities | Epileptic Form Activity

3) Pharmacology and Drug Testing
Toxicology

4) Unit and Network Activity
Spike Sorting | Spike Determination

5) Muscle Propagation & Pacing
Examples
 
6) QT Prolongation
Examples
 
Click on the individual pictures to obtained detailed examples of a selection of various slice and culture preparations that have been studied with the MED64 System.
  CNS / PNS Myocardium and Smooth Muscle

Acute Slices

Hippocampus Spinal Cord Atrium Ventricular Slice
Amygdala SCN Smooth Muscle  
Retina Cortex.
Hypothalamus.
Brain stem.
and MORE   
   
Slice Cultures Hippocampal Slice SCN Slice
Cerebellum
 
Slice Co-Cultures      
Dissociated Cultures DRG Cells

Hippocampus.  Cortex.
and MORE.

  Myocardial Cells
       

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